I ChyzheuskayaBelarusian Medical Academy of Postgraduate Education, Belarus
Title: Lipid peroxidation and the antioxidant system in children with juvenile idiopathic arthritis
Objective: to determine the indicators of lipid peroxidation (LPO) and the content of fat-soluble (ACL) and water-soluble (ACW) substances in the blood serum of children with juvenile idiopathic arthritis (JIA).
Methods: Research was carried out in the rheumatology department of 4th City Children's Clinical Hospital, Minsk, Belarus. 30 children with JIA and 30 healthy children were examined. Determination of indicators of lipid peroxidation (LPO) and the content of ACL and ACW in blood serum was carried out at the Central Research Laboratory. Statistical data processing was carried out by traditional methods of variation statistics on a personal computer using the Statsoft Statistica 10.0 program.
Discussion: A significant (P<0.05) increase in the level of LPO products in the blood serum of children with JIA was established when compared with healthy children: the content of diene conjugates in the blood of children with JIA was 3.26±0.54 units opt.pl., in healthy children - 1.65±0.4 units opt.pl., the content of dienketones in children with JIA - 4.22±0.39 units opt.pl., in healthy children - 0.19± 0.08 units opt.pl., the content of malondialdehyde in children with JIA - 9.14±1.84 µmol/l, in healthy children - 6.96±1.42 µmol/l. A significant (?<0.01) decrease in the content of ACW and ACL in the blood serum of children with JIA was established when compared with the control group: the content of ACW in children with JIA was 11.52±5.6 µmol/l, in healthy children it was 13.72±5.24 µmol/l, ACL content in children with JIA - 8.11±3.95 µmol/l, in healthy children - 8.81±3.5 µmol/l.
Conclusions: The obtained results indicate the activation of lipid peroxidation processes and disruption of antioxidant defense processes in children with JIA, which may contribute to maintaining a high intensity of immune inflammation in this pathology.