Virtual Conference
Pediatrics 2022

Olga Smilevska Spasova

Institute for respiratory diseases in children-Kozle, R. N. Macedonia

Title: Severe Pneumonia requiring ICU care caused by Human Metapneumovirus (hMPV) in infants


Introduction: The human Metapneumovirus (hMPV) usually causes mild, cold-like symptoms, but in infants it can lead to serious problems like bronchiolitis and pneumonia. We observed an increased number of hospitalized children under the age of 5 that had severe pneumonia, requiring oxygen support and prolonged hospital stay of at least two weeks. We suspected that an invasive virus was circulating in the community resulting in an increased number of cases of severe pneumonia in infants. Our aim was to try to identify the respiratory pathogen that may have been responsible. 
Method: Retrospectively, we analyzed in total 18 children under the age of 5, which were hospitalized in our unit in a period of one month (01.04-30.04.2022). All of the patients were with acute community acquired pneumonia and had no other prehistory of chronic health issues. Other than the standard laboratory, microbiological and imaging techniques for diagnosing pneumonia, all the patients underwent a complete molecular respiratory RT-qPCR panel for 19 viruses and multiplex PCR for 7 bacteria. 
Results: With the above mentioned method Adenovirus was isolated in 5 children (27%), Parainfluenza in 5 children (27%), hMPV in 4 patients (22%) and RSV in 4 patients (22%). Bacteria H. Influenzae was found in 7 children (39%) and Streptococcus pneumoniae in 4 patients (22%). 50 % of the hospitalized children had a mixed viral and bacterial infection. In all of the patients that had severe pneumonia requiring oxygen support, hMPV was isolated. 
Conclusion: hMPV may be associated with worsening of the clinical and radiologic outcome of pneumonia in young children


Olga Smilevska Spasova, MD is a graduate of Ss. Cyril and Methodius University Medical faculty, where she also finished her residency program in Pediatrics. In 2015 she completed a Masters of public health program also from Ss. Cyril and Methodius University School of Medicine. She attended an undergraduate program in Biology at the University of Windsor in Ontario, Canada. Olga is a highly motivated and dedicated pediatrician committed to patient welfare, organization of healthcare, including and prioritizing health promotion and disease prevention through public health initiatives. Spasova has been practicing at the Institute for Respiratory Diseases in Children Kozle in Skopje Republic of N. Macedonia since 2014. The hospital during the Sars covid 19 pandemic was designated the State treatment center for Covid 19 for children in the country. She was a member of the team responsible for the treatment of children during the 2019 measles pandemic in N.Macedonia. She specializes in the treatment of acute and chronic respiratory illnesses in children. At the hospital she is responsible for the organization, coordination of the hospital consultation, prevention, triage and admitting office.