Central nervous system manifestations are a known complication in 0.1% of Mycoplasma pneumoniae infections. In this case report we present an 11 year old boy with meningo-encephalitis and pneumonia of the right lower lobe. There is clear seroconversion of Mycoplasma pneumoniae. After administration of adequate antibiotic therapy, there was complete clinical recovery. Mycoplasma pneumoniae should be taken into consideration when neurological symptoms complicate a respiratory tract infection. 

Zoë is a 3rd year pediatrician in training at Gent University hospital, Belgium.